Manchester United will be looking to secure at least one point that they need to make it into the knockout rounds of the Europa League when they face Sheriff Tiraspol in Group E on Thursday.
The hosts are currently three points behind Real Sociedad in second place, while the visitors are third in the group having picked up just one win so far.
The Red Devils are still playing catchup in the race for a top-four spot in the Premier League, and it is a similar story in the Europa League, with Real Sociedad still sitting at the top of Group E with 12 points.
A remaekable showing from stand-in Omonia Nicosia goalkeeper Francis Uzoho eventaully went unrewarded on matchday four, as Scott McTominay scored the late winner to leave Matchester United requiring just one point from their final two matches to progress to the knockout stages.
Manchester United enter the contest having gone unbeaten in their last six matches across all competitions, and despite losing to Real Sociedad at Old Trafford on September 8, not since the 1996-97 Champions League have they lost two group-stage European matches in a single campaign at home.
Sheriff Tiraspol began life in the Europa League with an impressive 3-0 victory over Omonia Nicosia, but they have since struggled to mix with the Group E big boys.
After losing 2-0 to Manchester United on matchday two, Sheriff have since suffered a pair of defeats to Real Sociedad by an aggregate score of 5-0, and any slim hopes the visitors have of making the knockout stages will be dashed if they lose at Old Trafford.
Battling Omonia Nicosia for the consolation prize of Europa Conference League football is now the most likely outcome for Sheriff, who suffered a rare top-flight defeat at the weekend, losing 1-0 to Petrocub.
Manchester United vs Sheriff Tiraspol head to head
These two teams have previously met on just one occasion in the Europa League on September 15, where Manchester United claimed a 2-0 away win.
Sheriff 0-2 Manchester United 15/09/22
Manchester United latest home form
Manchester United have recently been on a relatively good run of form at home, having lost just one of their six most recent matches. They defeated Tottenham Hotspur 2-0 in their last home game in the league. In their last five matches, they have scored six goals and conceded two.
Manchester United 3-1 Arsenal 04/09/22
Manchester United 0-1 Real Sociedad 08/09/22
Manchester United 1-0 Omonia Nicosia 13/10/22
Manchester United 0-0 Newcastle United 16/10/22
Manchester United 2-0 Tottenham Hotspur 19/10/22
Manchester United latest away form
Manchester United have recently been on a relatively good run of form on the road, having lost just one of their seven most recent matches. They drew 1-1 with Chelsea in their last away game in the league. In their last five matches, they have scored 11 goals and conceded 10.
Sheriff 0-2 Manchester United 15/09/22
Manchester City 6-3 Manchester United 02/10/22
Omonia Nicosia 2-3 Manchester United 06/10/22
Everton 1-2 Manchester United 09/10/22
Chelsea 1-1 Manchester United 22/10/22
Sheriff Tiraspol latest home form
Sheriff Tiraspol have recently been on a relatively good run of form at home, having lost just two of their nine most recent matches. They defeated CSF Balti 2-1 in their last home game in the league. In their last five matches, they have scored five goals and conceded five.
Sheriff 0-2 Manchester United 15/09/22
Sheriff 0-0 Zimbru 18/09/22
Sheriff 3-0 Sfintul Gheorghe 02/10/22
Sheriff 0-2 Real Sociedad 06/10/22
Sheriff 2-1 CSF Balti 16/10/22
Sheriff Tiraspol latest away form
Sheriff Tiraspol have recently kept a mixed run of form on the road, having won just two of their four most recent matches. They were beaten 1-0 by Petrocub in their last away game in the league. In their last five matches, they have scored 10 goals and conceded four.
Omonia Nicosia 0-3 Sheriff 08/09/22
Dinamo-Auto 0-1 Sheriff 09/10/22
Real Sociedad 3-0 Sheriff 13/10/22
Speranta Drochia 0-6 Sheriff 19/10/22
Petrocub 1-0 Sheriff 23/10/22
Manchester United news
Raphael Varane was forced off at Stamford Bridge at the weekend with a knee injury, and he is not expected to play for Manchester United again before the World Cup.
As a result, Victor Lindelof will deputise this week, while Aaron Wan-Bissaka, Harry Maguire and Anthony Martial are all back in training.
Sheriff Tiraspol news
Sheriff Tiraspol right-back Armel Zohouri will sit this one out after being sent off in the 3-0 defeat to Real Sociedad on matchday four.
However, Moussa Kyabou and Iyayi Atiemwen are both eligible to return after serving suspensions of their own last time out, with Dumitru Celeadnic starting in goal.
Prediction and Odds
Taking away just one point from Stamford Bridge would have disappointed a dominant Manchester United, who defeated Tottenham Hotspur at Old Trafford last week.
The hosts should have no trouble inflicting similar punishment on Sheriff Tiraspol at the Theatre of Dreams, picking up all three points in the process.
Odds: 1 1.72 X 2.10 X 3.12
Probable outcomes
Manchester United 1-0 Sheriff
Manchester United 2-0 Sheriff
Manchester United 2-1 Sheriff
Manchester United 3-0 Sheriff
Manchester United 3-1 Sheriff